Investigation of para-sulfonatocalix[n]arenes [n = 6, 8] as potential chelates for 230U - Université de Nantes Accéder directement au contenu
Article Dans Une Revue Journal- Chemical Society Dalton Transactions Année : 2010

Investigation of para-sulfonatocalix[n]arenes [n = 6, 8] as potential chelates for 230U

Gilles F Montavon
U. Repinc
  • Fonction : Auteur
C. Apostolidis
  • Fonction : Auteur
F. Bruchertseifer
  • Fonction : Auteur
K. Abbas
  • Fonction : Auteur
A. Morgenstern

Résumé

Literature reports of the efficacy of para-sulfonatocalix[6]- and calix[8]-arenes as U(VI) complexants indicated that they might be useful for in vivo chelation of the novel therapeutic alhpa-emitter 230U. We have studied the complexation of U(VI) with para-sulfonatocalix[6]arene and para-sulfonatocalix[8]arene by time resolved laser induced fluorescence spectroscopy and using competition methods with Chelex resin and 4-(2-pyridylazo)resorcinol in simplified and in biological media. New thermodynamic parameters describing the stability of U(VI)-para-sulfonatocalix[n]arene [n = 6, 8] complexes were obtained. Although the interactions are strong, the complexes do not exhibit sufficient stability to compete with carbonate ions and serum proteins for complexation of U(VI) under physiological conditions.

Domaines

Radiochimie
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Dates et versions

in2p3-00450808 , version 1 (27-01-2010)

Identifiants

Citer

Gilles F Montavon, U. Repinc, C. Apostolidis, F. Bruchertseifer, K. Abbas, et al.. Investigation of para-sulfonatocalix[n]arenes [n = 6, 8] as potential chelates for 230U. Journal- Chemical Society Dalton Transactions, 2010, 39, pp.1366-1374. ⟨10.1039/b918426k⟩. ⟨in2p3-00450808⟩
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